https://wiki.socr.umich.edu/api.php?action=feedcontributions&user=PaulaEaston&feedformat=atomSOCR - User contributions [en]2022-08-16T04:16:17ZUser contributionsMediaWiki 1.31.6https://wiki.socr.umich.edu/index.php?title=AP_Statistics_Curriculum_2007_IntroDesign&diff=5027AP Statistics Curriculum 2007 IntroDesign2007-08-10T04:41:05Z<p>PaulaEaston: /* A study of aortic valve-sparing repair<sup>*</sup> */</p>
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<div>[[AP_Statistics_Curriculum_2007 | General Advance-Placement (AP) Statistics Curriculum]] - Design and Experiments<br />
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==Design and Experiments==<br />
''Design of experiments'' refers of the blueprint for planning a study or experiment, performing the data collection protocol and controlling the study parameters for accuracy and consistency. Design of experiments only makes sense in studies where variation, chance and uncertainly are present and unavoidable. Data, or information, is typically collected in regard to a specific process or phenomenon being studied to investigate the effects of some controlled variables (independent variables or predictors) on other observed measurements (responses or dependent variables). Both types of variables are associated with specific observational units (living beings, components, objects, materials, etc.)<br />
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==Approach==<br />
The following are the most common components used in Experimental Design.<br />
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===Comparison===<br />
To make inference about effects, associations or predictions, one typically has to compare different groups subjected to distinct conditions. This allows contrasting observed responses and underlying group differences which ultimately may lead to inference on relations and influence between controlled and observed variables.<br />
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===Randomization===<br />
The second fundamental design principle is randomization. It requires that we make allocation of (controlled variables) treatments to units using some [[SOCR_EduMaterials_Activities_RNG | random mechanism]]. This will simply guarantees that effects that may be present is the units, but not incorporated in the model, are equidistributed amongst all groups and are therefore unlikely to significantly effect our group comparisons at the end of the statistical inference or analysis (as these effects, if present, will be similar within each group).<br />
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===Replication===<br />
All measurements we make, observations we acquire or data we collect is subject to variation, as [[SOCR_EduMaterials_Activities_RNG | there are no completely deterministic processes]]. As we try to make inference about the process that generated the observed data (not the sample data itself, even though our statistical analysis are data-driven and therefore based on the observed measurements), the more data we collect (unbiasly) the stronger our inference is likely to be. Therefore, repeated measurements intuitively would allow is to tame the variability associated with the phenomenon we study.<br />
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===Blocking===<br />
Blocking is related to randomization. The difference is that we use blocking when we know ''a priori'' of certain effects of the observational units on the response measurements (e.g., when studying the effects of hormonal treatments on humans, gender plays a significant role). We arrange units into groups (blocks) that are similar to one another when we design an experiment in which certain unit characteristics are known to affect the response measurements. Blocking reduces known and irrelevant sources of variation between units and allows greater precision in the estimation of the source of variation in the study.<br />
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===Orthogonality===<br />
Orthogonality allows division of complex relations, variation into separate (independent/orthogonal) contrasts, or factors, that can be studies efficiently and autonomously. Often, these contrasts may be represented by vectors, where sets of orthogonal contrasts are uncorrelated and may be independently distributed. Independence implies that each orthogonal contrast provides complementary information to other contrasts (i.e., other treatments). The goal is to completely decompose the variance or the relations of the observed measurements into independent components (e.g., like [http://en.wikipedia.org/wiki/Taylor_expansion Taylor expansion] allows polynomial decomposition of smooth functions, where the polynomial base functions are easy to differentiate, integrate, etc.) This will, of course, allow easier interpretation of the statistical analysis and the findings of the study.<br />
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==Model Validation==<br />
All of the components in the [[AP_Statistics_Curriculum_2007_IntroDesign#Approach | approach/methods section]] need to be validated but the major one is the independence assumption.<br />
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==Computational Resources: Internet-based SOCR Tools==<br />
* [http://www.socr.ucla.edu/htmls/SOCR_ChoiceOfStatisticalTest.html How to choose a statistical test based on a study design?]<br />
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==Examples & hands-on activities==<br />
===A [[AP_Statistics_Curriculum_2007_IntroDesign#References | study of aortic valve-sparing repair<sup>*</sup>]]===<br />
* This study sought to establish whether there was a difference in outcome after aortic valve repair with autologous pericardial leaflet extension in acquired versus congenital valvular disease. One 128 patients underwent reparative aortic valve surgery at UCLA from 1997 through 2005 for acquired or congenital aortic valve disease. The acquired group (43/128) (34%) had a mean age of 56.4 <math>\pm</math> 20.3 years (range, 7.8—84.6 years) and the congenital group (85/128) (66%) had a mean age of 16.9 <math>\pm</math>19.2 years (range, 0.3—82 years). The endpoints of the study were mortality and reoperation rates.<br />
* In this case the ''units'' are heart disease patients. These were split into two groups (acquired or congenital) and blocked by gender (male/female). The treatment allied on the two groups was ''aortic valve repair with autologous pericardial leaflet extension''.<br />
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<hr><br />
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==References==<br />
* [http://www.loni.ucla.edu/~dinov/publications.html David De La Zerda, Oved Cohen, Michael C. Fishbein, Jonah Odim, Carlos A Calderon, Diana Hekmat, Ivo Dinov and Hillel Laks]. [http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T35-4MNRN1T-2-7&_cdi=4937&_user=4423&_orig=search&_coverDate=12%2F27%2F2006&_sk=999999999&view=c&wchp=dGLbVlb-zSkWA&md5=e0692b12bb461286315fd4bdf2db5c4f&ie=/sdarticle.pdf Aortic valve-sparing repair with autologous pericardial leaflet extension has a greater early re-operation rate in congenital versus acquired valve disease.] European Journal of Cardio-Thoracic Surgery, February 2007; 31: 256-260 . PMID: 17196393, doi:10.1016/j.ejcts.2006.11.027.<br />
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<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
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{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=AP_Statistics_Curriculum_2007_IntroDesign}}</div>PaulaEastonhttps://wiki.socr.umich.edu/index.php?title=PaulaEaston_2007&diff=5010PaulaEaston 20072007-08-08T18:33:44Z<p>PaulaEaston: /* Instructions */</p>
<hr />
<div>==[[SOCR_CommunityPortal_Events_Aug2007 | SOCR 2007 Workshop-Specific Community Pages]] -- [[SOCR_Events_Aug2007 | SOCR/CAUSE Workshop]]==<br />
<br />
Please try to keep these pages as clean and hierarchically organized as possible. Refer to the [[SOCR_EduMaterials_GuidelinesWikiEditing | SOCR Editing Guide]] before you begin contributing to these resources. To avoid making changes that collide with revisions by others, please only edit pages under your name.<br />
<br />
===Paula Easton===<br />
<br />
==Paula Easton's Activities Home Page==<br />
<br />
==Activity 1==<br />
<br />
* [[ PaulaEaston_2007_MyFirst Activity_080807]]<br />
<br />
<br />
<br />
<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
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<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
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{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}</div>PaulaEastonhttps://wiki.socr.umich.edu/index.php?title=PaulaEaston_2007&diff=5008PaulaEaston 20072007-08-08T18:33:22Z<p>PaulaEaston: /* Instructions */</p>
<hr />
<div>==[[SOCR_CommunityPortal_Events_Aug2007 | SOCR 2007 Workshop-Specific Community Pages]] -- [[SOCR_Events_Aug2007 | SOCR/CAUSE Workshop]]==<br />
<br />
Please try to keep these pages as clean and hierarchically organized as possible. Refer to the [[SOCR_EduMaterials_GuidelinesWikiEditing | SOCR Editing Guide]] before you begin contributing to these resources. To avoid making changes that collide with revisions by others, please only edit pages under your name.<br />
<br />
===Paula Easton===<br />
<br />
==Paula Easton's Activities Home Page==<br />
<br />
==Activity 1==<br />
<br />
* [[ PaulaEaston_2007_MyFirst Activity_080807]]<br />
<br />
<br />
<br />
==Instructions==<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}</div>PaulaEastonhttps://wiki.socr.umich.edu/index.php?title=PaulaEaston_2007_MyFirst_Activity_080807&diff=5007PaulaEaston 2007 MyFirst Activity 0808072007-08-08T18:32:29Z<p>PaulaEaston: </p>
<hr />
<div>==Instructions==<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}</div>PaulaEastonhttps://wiki.socr.umich.edu/index.php?title=PaulaEaston_2007&diff=5003PaulaEaston 20072007-08-08T18:32:07Z<p>PaulaEaston: /* Instructions */</p>
<hr />
<div>==[[SOCR_CommunityPortal_Events_Aug2007 | SOCR 2007 Workshop-Specific Community Pages]] -- [[SOCR_Events_Aug2007 | SOCR/CAUSE Workshop]]==<br />
<br />
Please try to keep these pages as clean and hierarchically organized as possible. Refer to the [[SOCR_EduMaterials_GuidelinesWikiEditing | SOCR Editing Guide]] before you begin contributing to these resources. To avoid making changes that collide with revisions by others, please only edit pages under your name.<br />
<br />
===Paula Easton===<br />
<br />
==Paula Easton's Activities Home Page==<br />
<br />
==Activity 1==<br />
<br />
* [[ PaulaEaston_2007_MyFirst Activity_080807]]<br />
<br />
==Instructions==<br />
==Instructions==<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}</div>PaulaEastonhttps://wiki.socr.umich.edu/index.php?title=PaulaEaston_2007&diff=4994PaulaEaston 20072007-08-08T18:29:06Z<p>PaulaEaston: </p>
<hr />
<div>==[[SOCR_CommunityPortal_Events_Aug2007 | SOCR 2007 Workshop-Specific Community Pages]] -- [[SOCR_Events_Aug2007 | SOCR/CAUSE Workshop]]==<br />
<br />
Please try to keep these pages as clean and hierarchically organized as possible. Refer to the [[SOCR_EduMaterials_GuidelinesWikiEditing | SOCR Editing Guide]] before you begin contributing to these resources. To avoid making changes that collide with revisions by others, please only edit pages under your name.<br />
<br />
===Paula Easton===<br />
<br />
==Paula Easton's Activities Home Page==<br />
<br />
==Activity 1==<br />
<br />
* [[ PaulaEaston_2007_MyFirst Activity_080807]]<br />
<br />
==Instructions==<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=PaulaEaston_2007_MyFirst Activity_080807}}</div>PaulaEastonhttps://wiki.socr.umich.edu/index.php?title=PaulaEaston_2007&diff=4913PaulaEaston 20072007-08-08T17:54:39Z<p>PaulaEaston: /* My First Activities */</p>
<hr />
<div>==[[SOCR_CommunityPortal_Events_Aug2007 | SOCR 2007 Workshop-Specific Community Pages]] -- [[SOCR_Events_Aug2007 | SOCR/CAUSE Workshop]]==<br />
<br />
Please try to keep these pages as clean and hierarchically organized as possible. Refer to the [[SOCR_EduMaterials_GuidelinesWikiEditing | SOCR Editing Guide]] before you begin contributing to these resources. To avoid making changes that collide with revisions by others, please only edit pages under your name.<br />
<br />
===Paula Easton===<br />
<br />
==Paula Easton's Activities Home Page==<br />
<br />
==Activity 1==<br />
<br />
* [[ PaulaEaston_2007_MyFirst Activity_080807]]<br />
<br />
==Instructions==<br />
<br />
==Hands-on Activity to do - all participants==<br />
<br />
==Build in MS Word or Google Docs (docs.google.com/)==<br />
==Topic==<br />
* Generate some bivariate data (SOCR Modeler or via Experiments<br />
* Do some EDA plots<br />
* Do some analyses (e.g., diff of means, regression, ANOVA, etc.)<br />
* Fit <math>N(\mu, \sigma^2)</math> models to either dataset/variable<br />
* Discuss Model Differences<br />
* QQ (Data) probability plot<br />
* Notes<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=SOCR_CommunityPortal_Events_Aug2007}}</div>PaulaEastonhttps://wiki.socr.umich.edu/index.php?title=PaulaEaston_2007&diff=4883PaulaEaston 20072007-08-08T17:48:26Z<p>PaulaEaston: /* Paula Easton */</p>
<hr />
<div>==[[SOCR_CommunityPortal_Events_Aug2007 | SOCR 2007 Workshop-Specific Community Pages]] -- [[SOCR_Events_Aug2007 | SOCR/CAUSE Workshop]]==<br />
<br />
Please try to keep these pages as clean and hierarchically organized as possible. Refer to the [[SOCR_EduMaterials_GuidelinesWikiEditing | SOCR Editing Guide]] before you begin contributing to these resources. To avoid making changes that collide with revisions by others, please only edit pages under your name.<br />
<br />
===Paula Easton===<br />
<br />
==My First Activities==<br />
* [[ PaulaEaston_2007_MyFirst Activity_080807]]<br />
<br />
<br />
<br />
<br />
<hr><br />
* SOCR Home page: http://www.socr.ucla.edu<br />
<br />
{{translate|pageName=http://wiki.stat.ucla.edu/socr/index.php?title=SOCR_CommunityPortal_Events_Aug2007}}</div>PaulaEaston