# SOCR News JMM DC Session 2021

## Contents

## SOCR News & Events: 2021 JMM/AMS Special Session on Foundations of Data Science: Mathematical Representation, Computational Modeling, and Statistical Inference

## Overview

The volume, heterogeneity, and velocity of digital information is increasing exponentially and faster than our ability to manage, interpret and analyze it. Novel mathematical algorithms, reliable statistical techniques, and powerful computational tools are necessary to cope with the enormous proliferation of data in all aspects of human experiences. There are a number of mathematical strategies to represent, model, analyze, interpret and visualize complex, voluminous, and high-dimensional data. The talks in this session will present advanced and alternative mathematical strategies to handle difficult data science challenges using differential equations, topological embeddings, tensor-based, analytical, numerical optimization, algebraic, multiresolution, variational, probabilistic, statistical, and artificial intelligence methods. Biomedical, environmental, and imaging examples will demonstrate the applications of such mathematical techniques to longitudinal, complex-valued, complex-time indexed, and incongruent observations.

## Organizer

## Session Logistics

**Date/Time**: Saturday, January 9, 2021, 8:00 AM - 12:00 PM**Venue**: Walter E. Washington Convention Center, Washington, DC, 801 Mt. Vernon Place NW, Washington, DC.**Room**: TBD**Conference**: 2021 Joint Mathematics Meetings Meeting**Session Format**: 4-hour session, 8 20+5+5 minute talks**Equipment**: Computer projector and screen with HDMI connection only (no VGA!) Session room does not include overhead transparency projectors, computers/laptops, blackboards or whiteboards**AMS Special Session Manual**: AMS/JMM Session Manual**Paper Abstract Submission**- choose session SS 9A (due date: Sept 01, 2020)**COVID-19 Updates**: AMS Resources & Updates related to COVID-19.

## Speakers

*To be finalized in September 2020 ...*- Caroline Uhler (MIT):
*Multi-Domain Data Integration: From Observations to Mechanistic Insights*(Abstract 1163-62-32)

- Massive data collection holds the promise of a better understanding of complex phenomena and ultimately, of better decisions. An exciting opportunity in this regard stems from the growing availability of perturbation / intervention data (manufacturing, advertisement, education, genomics, etc.). In order to obtain mechanistic insights from such data, a major challenge is the integration of different data modalities (video, audio, interventional, observational, etc.). Using genomics and in particular the problem of identifying drugs for the repurposing against COVID-19 as an example, I will first discuss our recent work on coupling autoencoders in the latent space to integrate and translate between data of very different modalities such as sequencing and imaging. I will then present a framework for integrating observational and interventional data for causal structure discovery and characterize the causal relationships that are identifiable from such data. We end by a theoretical analysis of autoencoders linking overparameterization to memorization. In particular, I will characterize the implicit bias of overparameterized autoencoders and show that such networks trained using standard optimization methods implement associative memory. Collectively, our results have major implications for planning and learning from interventions in various application domains.

- Jeff M. Phillips (Utah):
*A Primer on the Geometry in Machine Learning*Abstract 1163-52-52)

- Machine Learning is a discipline filled with many simple geometric algorithms, the central task of which is usually classification. These varied approaches all take as input a set of n points in d dimensions, each with a label. In learning,the goal is to use this input data to build a function which predicts a label accurately on new data drawn from the same unknown distribution as the input data. The main difference in the many algorithms is largely a result of the chosen class of functions considered. This talk will take a quick tour through many approaches from simple to complex and modern,and show the geometry inherent at each step. Pit stops will include connections to geometric data structures, duality,random projections, range spaces, and core sets.

- Jonathan Niles-Weed, NYU/Courant/Center for Data Science:
*Statistical estimation under group actions*(Abstract 1163-62-41)

- A common challenge in the sciences is the presence of heterogeneity in data. Motivated by problems in signal processing and computational biology, we consider a particular form of heterogeneity where observations are corrupted by random transformations from a group (such as the group of permutations or rotations) before they can be collected and analyzed. We establish the fundamental limits of statistical estimation in such settings and show that the optimal rates of recovery are precisely governed by the invariant theory of the group. As a corollary, we establish rigorously the number of samples necessary to reconstruct the structure of molecules in cryo-electron microscopy. We also give a computationally efficient algorithm for a special case of this problem, and discuss conjectured statistical-computational gaps for the general case.
- Based on joint work with Afonso Bandeira, Ben Blum-Smith, Joe Kileel, Amelia Perry, Philippe Rigollet, Amit Singer, and Alex Wein.

- Ivo D. Dinov (University of Michigan):
*Data Science, Time Complexity, and Spacekime Analytics*(Abstract 1163-62-33)

- Human behavior, communication, and social interactions are profoundly augmented by the rapid immersion of digitalization and virtualization of all life experiences. This process presents important challenges of managing, harmonizing, modeling, analyzing, interpreting, and visualizing complex information. There is a substantial need to develop, validate, productize, and support novel mathematical techniques, advanced statistical computing algorithms, transdisciplinary tools, and effective artificial intelligence applications.
*Spacekime analytics*is a new technique for modeling high-dimensional longitudinal data. This approach relies on extending the notions of time, events, particles, and wavefunctions to complex-time (*kime*), complex-events (*kevents*), data, and inference-functions. We will illustrate how the kime-magnitude (longitudinal time order) and kime-direction (phase) affect the subsequent predictive analytics and the induced scientific inference. The mathematical foundation of spacekime calculus reveal various statistical implications including inferential uncertainty and a Bayesian formulation of spacekime analytics. Complexifying time allows the lifting of all commonly observed processes from the classical 4D Minkowski spacetime to a 5D spacekime manifold, where a number of interesting mathematical problems arise. Direct data science applications of spacekime analytics will be demonstrated using simulated data and clinical observations (e.g., sMRI, fMRI data).

## Resources

- Slides/papers: TBD

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