SOCR Events FTO Obesity Neuroimaging2010
SOCR News - Neuroimaging study of obesity and brain tissue loss using the SOCR computational libraries
SOCR volumetric Regression coefficient (unstandardized beta) maps for regional brain volume correlating with FTO, after adjusting for age and sex (Upper) compared to unthresholded regression coefficient maps for regional brain volume correlating with FTO, after adjusting for age, sex, and BMI (Lower). Unthresholded maps are shown (Lower) as there were no significant regions after correcting at 5% SOCR FDR in the whole brain analysis after adjusting for age, sex, and BMI. This is perhaps to be expected as FTO influences BMI. Images are displayed in radiological convention (left side of the brain shown on the right) and are displayed over a study-specific brain image template (MDT).
PNAS published the largest neuroimaging study to-date identifying the relations between obesity gene (FTO) and brain tissue loss using the SOCR computational libraries.
Reporting in the journal Proceedings of the National Academy of Sciences, UCLA investigators found that the FTO obesity gene is associated with a loss of brain tissue. This puts more than a third of the U.S. population at risk for a variety of diseases, such as Alzheimer's. This study used the SOCR computational libraries and SOCR Analyses to identify multivariate relations between subject demographic and imaging data.
See also
- PNAS Paper (April 2010): April J. Ho, Jason L. Stein, Xue Hua, Suh Lee, Derrek P. Hibar, Alex D. Leow, Ivo D. Dinov, Arthur W. Toga, Andrew J. Saykin, Li Shen, Tatiana Foroud, Nathan Pankratz, Matthew J. Huentelman, David W. Craig, Jill D. Gerber, April N. Allen, Jason J. Corneveaux, Dietrich A. Stephan, Charles S. DeCarli, Bryan M. DeChairo, Steven G. Potkin, Clifford R. Jack, Jr., Michael W. Weiner, Cyrus A. Raji, Oscar L. Lopez, James T. Becker, Owen T. Carmichael, Paul M. Thompson, and the Alzheimer's Disease Neuroimaging Initiative. (2010) A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. PNAS published ahead of print April 19, 2010, doi:10.1073/pnas.0910878107.
- Genetic Engineering and Biotechnology News
- ABC7, Eyewitness News
- NPR (April 2010)
- SOCR Home page: http://www.socr.ucla.edu
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